86357 - Molecular and Clinical Aspects of Signal Transduction Topography

Learning outcomes

Knowledge and understanding of the anatomical variations of the systems and the molecular basis of morphogenesis, including with regard to pathological situations, particularly with regard to regenerative medicine. Ability to gather and interpret relevant data for independent judgment in the field of human morphological sciences. Ability to transfer the knowledge gained in the field of morphology to a wide biomedical audience. Learning concepts and advanced technologies that will allow to better understand the topics of study of the following years.

Course contents

Signal transduction pathways of hematopoietic interest.

The hematopoietic cell hyerarchy: The hematopoietic stem cell, the progenitor cells, the mature precursors.

Signaling related at the stem cell level: the stem cell factor/cKIT system and control of survival, proliferation and homing of the hematopoietic stem cell

Signaling related to the progenitor/precursor level: The erythropoietin/erythropoietin receptor system

Relationship between entrinsic and intrinsic control of hematopoiesis 

Readings/Bibliography

The students will be strongly encouraged to take an independent approach to learning. They will be advaiced to adopt any international textbook in English available on-line. They will also be guided toward a critical use of internet-assisted documentation and histological archives of italian universities.

Teaching methods

Frontal lessons

Assessment methods

At the end of the course a written test with multiple choices will take place

Teaching tools

Slide presentations

Office hours

See the website of Anna Rita Franco Migliaccio