66274 - Industrial and Process Analytical Chemistry with Laboratory M

Course contents

Sampling theory, control charts, analysis of variance (ANOVA). Accreditation and test labs. ISO 9000 certification and registration. Basics of experimental design.

Principles of chromatographic separations: thermodynamics and kinetics of chromatographic separations (plate count and Van Deemter equation).

Gas chromatography. Characteristics of stationary phases and their classification. Chromatographic Peak Identification Methods: Retention Indices.

Principles and instruments for liquid / liquid chromatography. Stationary phases in HPLC.

Principles and instruments for ion chromatography. Optimization of chromatographic separations (GC and HPLC). Electrophoresis and TLC. Extraction and purification systems in solid phase.

Automated analytical methods. Elemental analysis.

Total internal reflection. Optical fibers. Attenuated total reflection (ATR). Diffuse reflectance UV-Vis spectroscopy. Near infrared spectroscopy: principles and industrial applications. Raman spectroscopy. Flameless atomic absortion spectrometry.

Analysis of surfaces by X-Ray methods. X-ray - matter interaction. Basic of x-ray absorption and emission spectroscopy. Photoelectron spectroscopy

Thermal analysis. Thermogravimetry. Differential thermal analysis. Differential scanning calorimetry.

Hyphenated techniques. Detection in Mass Spectrometry. Basics of ICP-MS, GC-MS, SIMS.

Electroanalytical Chemistry and Sensors. Electron transfer. Mass transport (diffusion, convection, migration). Controlled potential techniques (cronoamperometry, cronocolumbometry, polarography, cyclic voltammetry)

Techniques for the trace and ultratrace analysis (anodic, cathodic and potentiometric stripping)

Modified electrodes for sensors applications

Amperometric sensors and biosensors

The course is completed by some laboratory work (practical).

PRE-REQUIREMENTS OF KNOWLEDGE AND ABILITY TO FOLLOW THE COURSE

In general, the knowledge and skills acquired in the following courses are required: Mathematics, Physics, Analytical Instrumental Chemistry

In particular, students must:

• be able to perform graphs and calibration curves
• be able to prepare solutions at a given concentration (also low concentration) with the appropriate precision
• Possess basic element of optics and algebra
• be able to use simple analytical instruments

Readings/Bibliography

1. H.H. Willard, R.R. Merritt, J.A. Dean, F.A. Settle. Instrumental Methods of Analysis 7th edition. Wadsworth Publishing Company, 1988
2. J.C. Miller and J.N. Miller, Statistics and Chemometrics for Analytical Chemistry, 6^th ed., Prentice Hall (UK), 2010
3. D.A. Skoog, D.M. West, F.J. Holler, S.R. Crouch, Fondamenti di Chimica Analitica, III Ed., Edises, 2009.
4. K. A. Rubinson, J. F. Rubinson, Chimica Analitica Strumentale, Zanichelli, 2002
5. P.M.S. Monk "Fundamentals of Electroanalytical Chemistry" J. Wiley & Sons, New York, 2002.

Teaching methods

The course involves front lectures and laboratory work

Assessment methods

The assessment of the learning consists in final written exam on some selected research topics learned during the course.

The written exam is made up of a maximum of 10 items between: a) multiple-choice questions; B) open answer questions; C) execution of problems and exercises related to the acquired knowledge and skills acquired on the theoretical, practical and applied contents of the course. The test may also include questions related to previous knowledge not explicitly covered by the course but resulting essential for the understanding of the course.

The duration of the written test is 3 hours.

The use of textbooks, the periodic table, and lessons (or slides) is expressly forbidden. It is allowed to consult the laboratory notebook. It is compulsory to have a calculator (not allowed on tablet or cellular devices) and the need to draw millimeter charts (pencils, rulers, team, rubber, pencil sharpeners) if required

Examination, if passed, keeps its validity for the sessions scheduled for the full academic year

Teaching tools

Lecture slides and other material useful for exam preparation is made available to the student electronically via the Internet. . To get the teaching material the student must be connected to the site : http://campus.unibo.it/. Username and password are reserved for students enrolled at the University of Bologna and will be provided by the teacher.

Office hours

See the website of Marco Giorgetti

See the website of Domenica Tonelli

See the website of Sergio Zappoli