- Docente: Elena Maestrini
- Credits: 3
- SSD: BIO/18
- Language: Italian
- Teaching Mode: Traditional lectures
- Campus: Bologna
- Corso: Second cycle degree programme (LS) in Bioinformatics (cod. 0443)
Learning outcomes
Introduction to strategies and methods for genetic mapping of human
mendelian and complex traits.
Course contents
DNA variation in the human genome, genetic markers, genotyping
technologies
Browsing the human genome: introduction to the UCSC Human Genome
Browser
Linkage analysis: strategies for mapping genes involved in
mendelian disorders. The LOD score method
Genetic heterogeneity
Linkage analysis of complex disorders: non-parametric methods,
sib-pair analysis
Association analysis: Linkage disequilibrium mapping, case-control
studies, Transmission Disequilibrium Test
The HapMap project. SNP selection and tag SNPs
Computer practical exercises: some commonly used software for
genetic linkage and association analysis will be presented
Readings/Bibliography
Michael R Barnes, Ian C Gray. Bioinformatics for Geneticists
(Wiley)
Articoli e reviews fornite dal docente
Office hours
See the website of Elena Maestrini